PT  - JOURNAL ARTICLE
AU  - S Conradi
AU  - L O Ronnevi
AU  - O Vesterberg
TI  - Lead concentration in skeletal muscle in amyotrophic lateral sclerosis patients and control subjects.
AID  - 10.1136/jnnp.41.11.1001
DP  - 1978 Nov 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 1001--1004
VI  - 41
IP  - 11
4099  - http://jnnp.bmj.com/content/41/11/1001.short
4100  - http://jnnp.bmj.com/content/41/11/1001.full
SO  - J Neurol Neurosurg Psychiatry1978 Nov 01; 41
AB  - The concentration of lead in the vastus lateralis muscle was determined in patients with amyotrophic lateral sclerosis and control subjects by flameless atomic absorption spectrophotometry. No statistically significant differences were found between these groups, and in both the figures were of the same magnitude as those earlier reported for normal individuals. Increased plasma lead concentrations do not seem to cause a significant deposition of lead in skeletal muscle. Therefore, plasma rather than skeletal muscle is the more likely source if pathological amounts of lead enter the motoneurones via the retrograde axoplasmic flow in amyotrophic lateral sclerosis.