RT Journal Article
SR Electronic
T1 Lead concentration in skeletal muscle in amyotrophic lateral sclerosis patients and control subjects.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1001
OP 1004
DO 10.1136/jnnp.41.11.1001
VO 41
IS 11
A1 S Conradi
A1 L O Ronnevi
A1 O Vesterberg
YR 1978
UL http://jnnp.bmj.com/content/41/11/1001.abstract
AB The concentration of lead in the vastus lateralis muscle was determined in patients with amyotrophic lateral sclerosis and control subjects by flameless atomic absorption spectrophotometry. No statistically significant differences were found between these groups, and in both the figures were of the same magnitude as those earlier reported for normal individuals. Increased plasma lead concentrations do not seem to cause a significant deposition of lead in skeletal muscle. Therefore, plasma rather than skeletal muscle is the more likely source if pathological amounts of lead enter the motoneurones via the retrograde axoplasmic flow in amyotrophic lateral sclerosis.