RT Journal Article
SR Electronic
T1 Do patients with demyelinating disease have antibodies against human glial cells in their sera?
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 164
OP 167
DO 10.1136/jnnp.44.2.164
VO 44
IS 2
A1 P G Kennedy
A1 R P Lisak
YR 1981
UL http://jnnp.bmj.com/content/44/2/164.abstract
AB Cell-type-specific markers and indirect immunofluorescence were used to study immunoglobulin binding to glial cells in dissociated cell cultures of human foetal optic nerve, spinal cord and dorsal root ganglion in sera from patients with demyelinating diseases, other neurological diseases and normal controls. These various sera proved to be indistinguishable in that almost all of them contained immunoglobulin which bound weakly to all oligodendrocytes and fibroblasts, 5-25% of astrocytes and about 50% of Schwann cells.