RT Journal Article
SR Electronic
T1 Successuful treatment of paramyotonia congenita (Eulenburg): muscle stiffness and weakness prevented by tocainide.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 268
OP 271
DO 10.1136/jnnp.43.3.268
VO 43
IS 3
A1 K Ricker
A1 A Haass
A1 R Rüdel
A1 R Böhlen
A1 H G Mertens
YR 1980
UL http://jnnp.bmj.com/content/43/3/268.abstract
AB Recent studies have shown that the sodium conductance of the sarcolemma is disturbed in paramyotonia. Tocainide is a new antiarrhythmic agent which seems to reduce effectively sodium conductance. Eight patients with paramyotonia were treated with tocainide, whereby the paramyotonic stiffness and weakness brought about by cooling could be prevented.