PT  - JOURNAL ARTICLE
AU  - Tfelt-Hansen, P
AU  - Olesen, J
AU  - Aebelholt-Krabbe, A
AU  - Melgaard, B
AU  - Veilis, B
TI  - A double blind study of metoclopramide in the treatment of migraine attacks.
AID  - 10.1136/jnnp.43.4.369
DP  - 1980 Apr 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 369--371
VI  - 43
IP  - 4
4099  - http://jnnp.bmj.com/content/43/4/369.short
4100  - http://jnnp.bmj.com/content/43/4/369.full
SO  - J Neurol Neurosurg Psychiatry1980 Apr 01; 43
AB  - One hundred and fifty patients with migraine attacks attending the Copenhagen acute migraine clinic were treated either with metoclopramide 10 mg i.m. metoclopramide 20 mg as suppository or placebo in a double blind trial. All patients simultaneously or 30 minutes later received paracetamol 1 g and diazepam 5 mg orally. The nausea was relieved in 71% of the patients by placebo and bed rest, but metoclopramide was significantly (p = 0.04) more effective and relieved nausea in 86% of the patients. Metoclopramide did not by itself reduce the pain, but enhanced the effect of the analgesic or sedative medication. This effect, however, just failed to be statistically significant (p = 0.06).