RT Journal Article
SR Electronic
T1 Deficient catecholamine release as the basis of orthostatic hypotension in pernicious anaemia.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1053
OP 1055
DO 10.1136/jnnp.45.11.1053
VO 45
IS 11
A1 Eisenhofer, G
A1 Lambie, D G
A1 Johnson, R H
A1 Tan, E
A1 Whiteside, E A
YR 1982
UL http://jnnp.bmj.com/content/45/11/1053.abstract
AB A patient with peripheral neuropathy and orthostatic hypotension was found to have pernicious anaemia. Symptoms improved after vitamin B12 replacement therapy. Insulin tolerance testing showed that the patient lacked catecholamine, heart rate, and sweating responses to hypoglycaemia. This indicates that pernicious anaemia may cause orthostatic hypotension owing to failure of noradrenaline release.