RT Journal Article
SR Electronic
T1 Adult ceroid-lipofuscinosis: diagnostic value of biopsies and of neurophysiological investigations.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1056
OP 1059
DO 10.1136/jnnp.45.11.1056
VO 45
IS 11
A1 A Vercruyssen
A1 J J Martin
A1 C Ceuterick
A1 K Jacobs
A1 L Swerts
YR 1982
UL http://jnnp.bmj.com/content/45/11/1056.abstract
AB In a sibship of ten, three brothers presented with an adult form of ceroid-lipofuscinosis. The diagnosis was confirmed by necropsy of the first patient and was made by electron microscopy of eccrine sweat glands and of skeletal muscles in the two others. Somatosensory evoked potentials were characterised by biphasic, nearly monophasic, very high voltage complexes totally unlike those found in normal controls. Similar sensory evoked potentials were however recorded in other types of ceroid-lipofuscinosis. While electron microscopy of easily available tissues gives fairly specific results, sensory evoked potentials can bring supportive diagnostic evidence in adult ceroid-lipofuscinosis.