RT Journal Article
SR Electronic
T1 Detection of lymphocytes in malignant gliomas by monoclonal antibodies.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 734
OP 737
DO 10.1136/jnnp.46.8.734
VO 46
IS 8
A1 K Yasuda
A1 T Alderson
A1 J Phillips
A1 K Sikora
YR 1983
UL http://jnnp.bmj.com/content/46/8/734.abstract
AB Lymphocytes are not present in normal brain but are known to infiltrate malignant gliomas. The reasons for this infiltration and the signals involved are not understood. The lymphocyte content of 15 malignant gliomas removed at time of surgery was studied, using monoclonal antibodies to T and B cell surface antigens and immunofluorescence. An average of 41% of infiltrating cells possessed surface Ig, with 21% bearing the common T cell marker. There was no evidence of oligoclonal restriction of light chain types.