TY - JOUR T1 - Alexander's disease with Rosenthal fibre formation in an adult. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 399 LP - 403 DO - 10.1136/jnnp.47.4.399 VL - 47 IS - 4 AU - T J Walls AU - R A Jones AU - N Cartlidge AU - M Saunders Y1 - 1984/04/01 UR - http://jnnp.bmj.com/content/47/4/399.abstract N2 - The case of a woman who had a mild mental and physical handicap all her life is described. At the age of 39 years she began a progressive deterioration which terminated with her death after a year. CT scanning revealed basal ganglia calcification and at necropsy there was evidence of widespread generalised myelin loss with extensive Rosenthal fibre formation. The hypothesis that this may be an adult form of Alexander's disease is discussed. ER -