RT Journal Article
SR Electronic
T1 Peripheral neuropathy during longterm high-dose amiodarone therapy.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 576
OP 578
DO 10.1136/jnnp.48.6.576
VO 48
IS 6
A1 A G Fraser
A1 I N McQueen
A1 A H Watt
A1 M R Stephens
YR 1985
UL http://jnnp.bmj.com/content/48/6/576.abstract
AB Three patients developed peripheral neuropathy after taking amiodarone for more than 18 months. All had high serum concentrations of amiodarone and its desethyl metabolite; in one patient concentrations in a sural nerve biopsy were 80 times higher than in serum. Peripheral neuropathy is a complication of large doses of amiodarone taken over long periods.