TY - JOUR T1 - The response to isoniazid of action tremor in multiple sclerosis and its assessment using polarised light goniometry. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 87 LP - 89 DO - 10.1136/jnnp.49.1.87 VL - 49 IS - 1 AU - D A Francis AU - D Grundy AU - J R Heron Y1 - 1986/01/01 UR - http://jnnp.bmj.com/content/49/1/87.abstract N2 - Isonicotinic acid hydrazide (isoniazid) was evaluated in five patients as a treatment for the control of severe cerebellar action tremor occurring in multiple sclerosis. Oral doses of isoniazid BPC were increased every 2 weeks from 300 mg to 1200 mg daily over an 8 week period. Four patients reported considerable symptomatic benefit at doses ranging from 600 mg to 900 mg daily. Polarised light goniometry demonstrated a two to three-fold reduction of tremor in these patients when standard methods of clinical assessment showed only marginal improvement. ER -