PT  - JOURNAL ARTICLE
AU  - D A Francis
AU  - D Grundy
AU  - J R Heron
TI  - The response to isoniazid of action tremor in multiple sclerosis and its assessment using polarised light goniometry.
AID  - 10.1136/jnnp.49.1.87
DP  - 1986 Jan 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 87--89
VI  - 49
IP  - 1
4099  - http://jnnp.bmj.com/content/49/1/87.short
4100  - http://jnnp.bmj.com/content/49/1/87.full
SO  - J Neurol Neurosurg Psychiatry1986 Jan 01; 49
AB  - Isonicotinic acid hydrazide (isoniazid) was evaluated in five patients as a treatment for the control of severe cerebellar action tremor occurring in multiple sclerosis. Oral doses of isoniazid BPC were increased every 2 weeks from 300 mg to 1200 mg daily over an 8 week period. Four patients reported considerable symptomatic benefit at doses ranging from 600 mg to 900 mg daily. Polarised light goniometry demonstrated a two to three-fold reduction of tremor in these patients when standard methods of clinical assessment showed only marginal improvement.