RT Journal Article
SR Electronic
T1 Magnetic resonance imaging of experimental cerebral oedema.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1341
OP 1347
DO 10.1136/jnnp.49.12.1341
VO 49
IS 12
A1 D Barnes
A1 W I McDonald
A1 P S Tofts
A1 G Johnson
A1 D N Landon
YR 1986
UL http://jnnp.bmj.com/content/49/12/1341.abstract
AB Triethyl tin(TET)-induced cerebral oedema has been studied in cats by magnetic resonance imaging (MRI), and the findings correlated with the histology and fine structure of the cerebrum following perfusion-fixation. MRI is a sensitive technique for detecting cerebral oedema, and the distribution and severity of the changes correlate closely with the morphological abnormalities. The relaxation times, T1 and T2 increase progressively as the oedema develops, and the proportional increase in T2 is approximately twice that in T1. Analysis of the magnetisation decay curves reveals slowly-relaxing and rapidly-relaxing components which probably correspond to oedema fluid and intracellular water respectively. The image appearances taken in conjunction with relaxation data provide a basis for determining the nature of the oedema in vivo.