RT Journal Article
SR Electronic
T1 Relation of clinical, serological, morphological, and electrophysiological findings in galactocerebroside-induced experimental allergic neuritis.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 258
OP 264
DO 10.1136/jnnp.49.3.258
VO 49
IS 3
A1 G Stoll
A1 G Schwendemann
A1 K Heininger
A1 W Köhne
A1 H P Hartung
A1 R Seitz
A1 K V Toyka
YR 1986
UL http://jnnp.bmj.com/content/49/3/258.abstract
AB Rabbits were immunised repeatedly with bovine brain galactocerebroside. Almost all animals developed overt polyradiculoneuropathy. Circulating IgG antibodies to galactocerebroside in the serum and deposits of IgG in the spinal roots were detectable weeks before definite clinical, morphological, and electrophysiological alterations occurred. The levels of IgG antibody titres to galactocerebroside did not correlate with the severity of the clinical disease and of nerve conduction slowing. Remyelination and a virtually complete recovery of nerve dysfunction occurred although circulating antibodies to galactocerebroside were still present.