RT Journal Article
SR Electronic
T1 Chronic fatigue and myalgia syndrome: mitochondrial and glycolytic studies in skeletal muscle.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 743
OP 746
DO 10.1136/jnnp.50.6.743
VO 50
IS 6
A1 E Byrne
A1 I Trounce
YR 1987
UL http://jnnp.bmj.com/content/50/6/743.abstract
AB Clinical and biochemical findings in skeletal muscle in 11 patients with chronic fatigue myalgia syndromes of unknown aetiology are reported. All patients had severe asthenia for from one to 10 years with greatly limited exercise capacity and protracted exhaustion after minor exercise. Diffuse myalgia was prominent and was exacerbated for hours to days after exercise. Assay of skeletal muscle carnitine, phosphorylase, all glycolytic enzymes and the mitochondrial marker enzymes monoamine oxidase, isocitrate dehydrogenase and cytochrome oxidase were normal. These findings lend no support to the presence of a major defect in muscle intermediary energy pathways in this syndrome.