@article {Weinberger94, author = {D R Weinberger and K F Berman and M Iadarola and N Driesen and R F Zec}, title = {Prefrontal cortical blood flow and cognitive function in Huntington{\textquoteright}s disease.}, volume = {51}, number = {1}, pages = {94--104}, year = {1988}, doi = {10.1136/jnnp.51.1.94}, publisher = {BMJ Publishing Group Ltd}, abstract = {To examine the relationship between cortical physiology and dementia in Huntington{\textquoteright}s disease, rCBF during three different behavioural conditions, one of which emphasised prefrontal cognition, was determined by xenon-133 inhalation in 14 patients with Huntington{\textquoteright}s disease and in matched controls. Cortical rCBF was not reduced in Huntington{\textquoteright}s disease patients even while they manifested overt prefrontal-type cognitive deficits. Caudate atrophy on CT and rCBF were significantly correlated, but only during the prefrontal behaviour where the correlation was positive. These results suggest a qualification of the subcortical dementia concept as applied to Huntington{\textquoteright}s disease and implicate an interaction between pathology that is subcortical and cognitive function that is cortical.}, issn = {0022-3050}, URL = {https://jnnp.bmj.com/content/51/1/94}, eprint = {https://jnnp.bmj.com/content/51/1/94.full.pdf}, journal = {Journal of Neurology, Neurosurgery \& Psychiatry} }