%0 Journal Article %A D R Weinberger %A K F Berman %A M Iadarola %A N Driesen %A R F Zec %T Prefrontal cortical blood flow and cognitive function in Huntington's disease. %D 1988 %R 10.1136/jnnp.51.1.94 %J Journal of Neurology, Neurosurgery & Psychiatry %P 94-104 %V 51 %N 1 %X To examine the relationship between cortical physiology and dementia in Huntington's disease, rCBF during three different behavioural conditions, one of which emphasised prefrontal cognition, was determined by xenon-133 inhalation in 14 patients with Huntington's disease and in matched controls. Cortical rCBF was not reduced in Huntington's disease patients even while they manifested overt prefrontal-type cognitive deficits. Caudate atrophy on CT and rCBF were significantly correlated, but only during the prefrontal behaviour where the correlation was positive. These results suggest a qualification of the subcortical dementia concept as applied to Huntington's disease and implicate an interaction between pathology that is subcortical and cognitive function that is cortical. %U https://jnnp.bmj.com/content/jnnp/51/1/94.full.pdf