RT Journal Article
SR Electronic
T1 Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1101
OP 1109
DO 10.1136/jnnp.50.9.1101
VO 50
IS 9
A1 Neary, D
A1 Snowden, J S
A1 Shields, R A
A1 Burjan, A W
A1 Northen, B
A1 MacDermott, N
A1 Prescott, M C
A1 Testa, H J
YR 1987
UL http://jnnp.bmj.com/content/50/9/1101.abstract
AB Single photon emission tomographic imaging of the brain using 99mTc HM-PAO was carried out in patients with a clinical diagnosis of Alzheimer's disease, non-Alzheimer frontal-lobe dementia, and progressive supranuclear palsy. Independent assessment of reductions in uptake revealed posterior hemisphere abnormalities in the majority of the Alzheimer group, and selective anterior hemisphere abnormalities in both other groups. The findings were consistent with observed patterns of mental impairment. The imaging technique has potential value in the differential diagnosis of primary cerebral atrophy.