PT  - JOURNAL ARTICLE
AU  - R N Rosenberg
AU  - C Banner
TI  - Normal cerebellar glutamate dehydrogenase protein in spinocerebellar degeneration.
AID  - 10.1136/jnnp.52.5.666
DP  - 1989 May 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 666--668
VI  - 52
IP  - 5
4099  - http://jnnp.bmj.com/content/52/5/666.short
4100  - http://jnnp.bmj.com/content/52/5/666.full
SO  - J Neurol Neurosurg Psychiatry1989 May 01; 52
AB  - Immunochemical analyses (Western blots) of cerebellar homogenates for glutamate dehydrogenase (GDH) from patients with spinocerebellar degeneration and control subjects were conducted. Four patients with autosomal dominant Joseph disease type of spinocerebellar degeneration, one patient with autosomal dominant olivopontocerebellar degeneration and four control subjects were studied. GDH was of the same molecular weight and amount in all patients and control subjects. These data together with normal GDH activity from these same homogenates published previously support the view that GDH is not involved in the pathogenesis of these types of dominantly inherited spinocerebellar degeneration.