PT  - JOURNAL ARTICLE
AU  - A G Kermode
AU  - I F Moseley
AU  - B E Kendall
AU  - D H Miller
AU  - D G MacManus
AU  - W I McDonald
TI  - Magnetic resonance imaging in Leber's optic neuropathy.
AID  - 10.1136/jnnp.52.5.671
DP  - 1989 May 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 671--674
VI  - 52
IP  - 5
4099  - http://jnnp.bmj.com/content/52/5/671.short
4100  - http://jnnp.bmj.com/content/52/5/671.full
SO  - J Neurol Neurosurg Psychiatry1989 May 01; 52
AB  - Thirteen males with Leber's optic neuropathy had magnetic resonance imaging (MRI) of the brain, and in eight the optic nerves were imaged using STIR (Short Time Inversion Recovery) sequences. All optic nerve scans were abnormal. In seven with bilateral visual loss four showed bilateral increased optic nerve signal and three unilateral increase. The involvement was of the mid and posterior intra-orbital sections over three 5 mm slices or more with sparing of the anterior portion. One patient with unilateral visual loss had increased signal only on the affected side. Brain MRI was normal, in marked contrast to the findings in clinically isolated optic neuritis in which multiple white matter lesions are seen in the majority.