RT Journal Article
SR Electronic
T1 Tyrosine hydroxylase and levodopa responsive dystonia.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 112
OP 114
DO 10.1136/jnnp.52.1.112
VO 52
IS 1
A1 N A Fletcher
A1 I J Holt
A1 A E Harding
A1 T G Nygaard
A1 J Mallet
A1 C D Marsden
YR 1989
UL http://jnnp.bmj.com/content/52/1/112.abstract
AB It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.