RT Journal Article
SR Electronic
T1 Fulminant monophasic multiple sclerosis, Marburg's type.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 918
OP 921
DO 10.1136/jnnp.53.10.918
VO 53
IS 10
A1 Johnson, M D
A1 Lavin, P
A1 Whetsell, W O
YR 1990
UL http://jnnp.bmj.com/content/53/10/918.abstract
AB The clinical, neuroradiological and necropsy findings are described in a 49 year old woman with long-standing idiopathic pulmonary haemosiderosis and acute monophasic multiple sclerosis (Marburg's type). Progression of the demyelinating process produced blindness and paraplegia over three weeks. At five weeks, magnetic reasonance imaging (MRI) studies showed lesions in the pons and left occipital lobe. The patient died 10 weeks after onset of symptoms. Necropsy examination revealed acute plaques in the optic chiasm, and the white matter around the lateral and fourth ventricle and spinal cord. Similarities between this and previously described cases of Marburg's disease are discussed.