RT Journal Article
SR Electronic
T1 Comparison of motor response to apomorphine and levodopa in Parkinson's disease.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1004
OP 1007
DO 10.1136/jnnp.53.11.1004
VO 53
IS 11
A1 P A Kempster
A1 J P Frankel
A1 G M Stern
A1 A J Lees
YR 1990
UL http://jnnp.bmj.com/content/53/11/1004.abstract
AB The magnitude and pattern of motor responses to single doses of subcutaneous apomorphine and oral levodopa were compared in 14 patients with Parkinson's disease. Although apomorphine produced much shorter motor responses than levodopa, the quality of response to the two drugs was virtually indistinguishable. These clinical observations support the notion that integrity of striatal post-synaptic dopamine receptors is a key determinant of responsiveness to dopaminergic treatment in Parkinson's disease.