PT  - JOURNAL ARTICLE
AU  - M K Sharief
AU  - E J Thompson
TI  - Immunoglobulin M in the cerebrospinal fluid: an indicator of recent immunological stimulation.
AID  - 10.1136/jnnp.52.8.949
DP  - 1989 Aug 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 949--953
VI  - 52
IP  - 8
4099  - http://jnnp.bmj.com/content/52/8/949.short
4100  - http://jnnp.bmj.com/content/52/8/949.full
SO  - J Neurol Neurosurg Psychiatry1989 Aug 01; 52
AB  - Using a sensitive new method for detecting oligoclonal immunoglobulin M (IgM) in unconcentrated cerebrospinal fluid (CSF), the intrathecal synthesis of IgM was correlated with that of free light chains in patients with multiple sclerosis, infections of the central nervous system and other neurological conditions. A strong correlation was found between the presence of oligoclonal IgM and that of free light chains in the CSF from patients with multiple sclerosis and infections of the central nervous system. No oligoclonal IgM response was observed in patients with non-inflammatory or non-infectious neurological conditions. This implies that oligoclonal IgM has the same diagnostic significance as free light chains.