PT  - JOURNAL ARTICLE
AU  - Dale, G E
AU  - Leigh, P N
AU  - Luthert, P
AU  - Anderton, B H
AU  - Roberts, G W
TI  - Neurofibrillary tangles in dementia pugilistica are ubiquitinated.
AID  - 10.1136/jnnp.54.2.116
DP  - 1991 Feb 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 116--118
VI  - 54
IP  - 2
4099  - http://jnnp.bmj.com/content/54/2/116.short
4100  - http://jnnp.bmj.com/content/54/2/116.full
SO  - J Neurol Neurosurg Psychiatry1991 Feb 01; 54
AB  - Ubiquitin, a protein thought to be involved in the ATP-dependent non-lysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.