RT Journal Article
SR Electronic
T1 Neurofibrillary tangles in dementia pugilistica are ubiquitinated.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 116
OP 118
DO 10.1136/jnnp.54.2.116
VO 54
IS 2
A1 Dale, G E
A1 Leigh, P N
A1 Luthert, P
A1 Anderton, B H
A1 Roberts, G W
YR 1991
UL http://jnnp.bmj.com/content/54/2/116.abstract
AB Ubiquitin, a protein thought to be involved in the ATP-dependent non-lysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.