PT - JOURNAL ARTICLE AU - D Laplane AU - N Attal AU - B Sauron AU - A de Billy AU - B Dubois TI - Lesions of basal ganglia due to disulfiram neurotoxicity. AID - 10.1136/jnnp.55.10.925 DP - 1992 Oct 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 925--929 VI - 55 IP - 10 4099 - http://jnnp.bmj.com/content/55/10/925.short 4100 - http://jnnp.bmj.com/content/55/10/925.full SO - J Neurol Neurosurg Psychiatry1992 Oct 01; 55 AB - Three cases of disulfiram induced Parkinsonism and frontal lobe-like syndrome associated with bilateral lesions of the lentiform nuclei on CT scan are reported. Symptoms developed either after an acute high dose of disulfiram (one case) or after several days to weeks of disulfiram treatment (two cases) and persisted over several years in two patients. These observations suggest that basal ganglia are one of the major targets of disulfiram neurotoxicity. The mechanisms of the lesions of basal ganglia may involve carbon disulfide toxicity.