@article {Clarke454, author = {C E Clarke and D I Shepherd and G M Yuill and J C Smaje and P B Wilson}, title = {Deficiencies in anti-acetylcholine receptor antibody measurement in myasthenia gravis.}, volume = {54}, number = {5}, pages = {454--456}, year = {1991}, doi = {10.1136/jnnp.54.5.454}, publisher = {BMJ Publishing Group Ltd}, abstract = {In a retrospective case note study of 86 patients with myasthenia gravis, 60 had an anti-acetylcholine receptor antibody assay performed by the regional immunology laboratory. Antibody was detected in 38\% which compares with 66-93\% in other series. Whilst the use of staphylococcal protein A to precipitate the antibody-receptor complex, rather than anti-human immunoglobulin, may be partly responsible for this low sensitivity, other methodological problems are likely to exist. It is suggested that this potentially critical assay becomes a subject for regular audit.}, issn = {0022-3050}, URL = {https://jnnp.bmj.com/content/54/5/454}, eprint = {https://jnnp.bmj.com/content/54/5/454.full.pdf}, journal = {Journal of Neurology, Neurosurgery \& Psychiatry} }