TY - JOUR T1 - Carcinomatous meningitis: antibody-guided therapy with I-131 HMFG1. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 260 LP - 265 DO - 10.1136/jnnp.54.3.260 VL - 54 IS - 3 AU - R P Moseley AU - J C Benjamin AU - R D Ashpole AU - N M Sullivan AU - J A Bullimore AU - H B Coakham AU - J T Kemshead Y1 - 1991/03/01 UR - http://jnnp.bmj.com/content/54/3/260.abstract N2 - Seven patients with carcinomatous meningitis were administered intrathecal I-131 labelled monoclonal antibody HMFG1. Clinical responses were seen in two patients, with a long term survivor at 32 months. Aseptic meningitis occurred in 4/7 patients, but more serious toxicity was observed in the form of seizures (2/7 patients) and myelosuppression (3/7 patients). Partial obliteration of the subarachnoid space was identified as a potential problem in patients with advanced disease. ER -