PT  - JOURNAL ARTICLE
AU  - Triggs, W J
AU  - Roe, C R
AU  - Rhead, W J
AU  - Hanson, S K
AU  - Lin, S N
AU  - Willmore, L J
TI  - Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin.
AID  - 10.1136/jnnp.55.3.209
DP  - 1992 Mar 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 209--211
VI  - 55
IP  - 3
4099  - http://jnnp.bmj.com/content/55/3/209.short
4100  - http://jnnp.bmj.com/content/55/3/209.full
SO  - J Neurol Neurosurg Psychiatry1992 Mar 01; 55
AB  - A 29 year old woman is described with severe hyperemesis gravidarum, atypical migraine, numerous admissions to hospital for psychiatric illness, non-epileptic seizures, and valproate-induced coma. Metabolic studies and measurement of [9,10(n)-3H]palmitate oxidation by cultured fibroblasts suggested a multiple acyl-CoA dehydrogenation disorder. Treatment with riboflavin abolished headaches and abnormal behaviour and normalised the plasma free carnitine level. Subtle defects in mitochondrial beta oxidation may be a treatable cause of disordered behaviour in adults.