TY - JOUR T1 - Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 683 LP - 688 DO - 10.1136/jnnp.54.8.683 VL - 54 IS - 8 AU - D H Miller AU - F Barkhof AU - I Berry AU - L Kappos AU - G Scotti AU - A J Thompson Y1 - 1991/08/01 UR - http://jnnp.bmj.com/content/54/8/683.abstract N2 - Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated. ER -