PT - JOURNAL ARTICLE AU - Miller, D H AU - Barkhof, F AU - Berry, I AU - Kappos, L AU - Scotti, G AU - Thompson, A J TI - Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. AID - 10.1136/jnnp.54.8.683 DP - 1991 Aug 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 683--688 VI - 54 IP - 8 4099 - http://jnnp.bmj.com/content/54/8/683.short 4100 - http://jnnp.bmj.com/content/54/8/683.full SO - J Neurol Neurosurg Psychiatry1991 Aug 01; 54 AB - Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated.