PT  - JOURNAL ARTICLE
AU  - Miller, D H
AU  - Barkhof, F
AU  - Berry, I
AU  - Kappos, L
AU  - Scotti, G
AU  - Thompson, A J
TI  - Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines.
AID  - 10.1136/jnnp.54.8.683
DP  - 1991 Aug 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 683--688
VI  - 54
IP  - 8
4099  - http://jnnp.bmj.com/content/54/8/683.short
4100  - http://jnnp.bmj.com/content/54/8/683.full
SO  - J Neurol Neurosurg Psychiatry1991 Aug 01; 54
AB  - Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated.