RT Journal Article
SR Electronic
T1 Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 683
OP 688
DO 10.1136/jnnp.54.8.683
VO 54
IS 8
A1 D H Miller
A1 F Barkhof
A1 I Berry
A1 L Kappos
A1 G Scotti
A1 A J Thompson
YR 1991
UL http://jnnp.bmj.com/content/54/8/683.abstract
AB Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated.