%0 Journal Article %A H A Ring %A M R Trimble %A D C Costa %A M S George %A P Verhoeff %A P J Ell %T Effect of vigabatrin on striatal dopamine receptors: evidence in humans for interactions of GABA and dopamine systems. %D 1992 %R 10.1136/jnnp.55.9.758 %J Journal of Neurology, Neurosurgery & Psychiatry %P 758-761 %V 55 %N 9 %X Vigabatrin is a specific gamma-aminobutyric acid transaminase inhibitor. The clinical use of this drug in the treatment of epilepsy has been sporadically linked to the development of psychosis. Using 123I-IBZM, a specific dopamine D2 receptor ligand and single photon emission tomography (SPET), one month of treatment with vigabatrin was associated with a decrease in specific binding of 123I-IBZM to D2 receptors in the left hemisphere basal ganglia. This change may provide one explanation for the development of psychosis in vulnerable patients. %U https://jnnp.bmj.com/content/jnnp/55/9/758.full.pdf