RT Journal Article
SR Electronic
T1 Peripheral neuropathy associated with monoclonal IgM anti-Pr2 cold agglutinins.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1178
OP 1183
DO 10.1136/jnnp.56.11.1178
VO 56
IS 11
A1 H J Willison
A1 G Paterson
A1 J Veitch
A1 G Inglis
A1 S C Barnett
YR 1993
UL http://jnnp.bmj.com/content/56/11/1178.abstract
AB A patient with a chronic, large fibre sensory neuropathy had an immunoglobulin M lambda monoclonal paraprotein reactive at titres in excess of 1/10(5) with NeuNAc(alpha 2-8)NeuNAc(alpha 2-3)Gal configured disialosyl groups present on the gangliosides GD1b, GT1b, GQ1b, and GD3. The paraprotein showed weaker reactivity with GD1a, GM3, and LM1 but no reactivity with GM2, GM1, or asialo-GM1. In addition, the paraprotein had cold agglutinating activity with anti-Pr2 specificity, Pr2 being an antigenic determinant on membrane glycoproteins or glycolipids in erythrocytes or both. A large fibre sensory neuropathy with monoclonal anti-disialosyl antibodies is an increasingly recognised form of paraproteinaemic neuropathy.