RT Journal Article SR Electronic T1 Severe psychiatric disturbance and abnormalities of the corpus callosum: review and case series. JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 85 OP 93 DO 10.1136/jnnp.56.1.85 VO 56 IS 1 A1 A S David A1 A Wacharasindhu A1 W A Lishman YR 1993 UL http://jnnp.bmj.com/content/56/1/85.abstract AB The association between developmental defects of the corpus callosum and major psychiatric disturbance is discussed with a review of published cases. Seven new cases are presented, of which four had clear psychotic symptoms, two receiving a diagnosis of schizophrenia. Of the remainder, one had a developmental disorder affecting social interaction and speech which could be classed as Asperger's syndrome, one had a personality disorder with depressive and conversion symptoms, and the last was an adolescent boy with severe behavioural problems. The difficulties in determining the precise relevance of the callosal anomalies to these clinical manifestations are discussed especially since the prevalence of such anomalies in the population is uncertain.