RT Journal Article
SR Electronic
T1 Anti-GM1 antibodies in patients with Guillain-Barré syndrome.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 8
OP 11
DO 10.1136/jnnp.55.1.8
VO 55
IS 1
A1 L H van den Berg
A1 J Marrink
A1 A E de Jager
A1 H J de Jong
A1 G W van Imhoff
A1 N Latov
A1 S A Sadiq
YR 1992
UL http://jnnp.bmj.com/content/55/1/8.abstract
AB Anti-GM1 antibodies were measured in 22 patients with the Guillain-Barré syndrome (GBS) and compared with anti-GM1 antibody activity in patients with other neurological or immunological diseases and in normal subjects. Four out of 22 patients with GBS had raised IgM, IgG, or IgA anti-GM1 antibody activities. All four patients were tetraparetic with only minimal or no sensory deficit. Three of the patients had highly raised antibody activity and showed severe residual deficits, while of the remaining patients with GBS, only one remained severely affected. One patient had anti-GM1 antibodies specific for GM1, whereas the other three patients showed antibody activity with asialo-GM1 or GD1b. The presence of anti-GM1 antibodies may define a subgroup of patients with GBS who have a poor prognosis.