RT Journal Article
SR Electronic
T1 Clinical heterogeneity and unusual presentations of Creutzfeldt-Jakob disease in Jewish patients with the PRNP codon 200 mutation.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1109
OP 1112
DO 10.1136/jnnp.56.10.1109
VO 56
IS 10
A1 J Chapman
A1 P Brown
A1 L G Goldfarb
A1 A Arlazoroff
A1 D C Gajdusek
A1 A D Korczyn
YR 1993
UL http://jnnp.bmj.com/content/56/10/1109.abstract
AB The cluster of Creutzfeldt-Jakob disease among Jews of Libyan origin is the largest in the world. It was found that the disease in this ethnic group is linked to a point mutation in codon 200 of the prion protein precursor gene. In this study the clinical data from 14 such patients are described, demonstrating wide phenotypic heterogeneity. The age of onset ranged from 34 to 65 years and the duration of disease from 2 to 66 months. Clinical features included cerebral, basal ganglia, brainstem, cerebellar, and spinal cord dysfunction. Uncommon features included fatal insomnia in one patient, pruritus in another, and demyelinating peripheral neuropathy in two.