RT Journal Article
SR Electronic
T1 Single photon emission computed tomography in long-term survivors of adult brain tumours.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 729
OP 733
DO 10.1136/jnnp.57.6.729
VO 57
IS 6
A1 K P Ebmeier
A1 K Booker
A1 A Gregor
A1 A Cull
A1 N Dougall
A1 R Sellar
A1 G M Goodwin
YR 1994
UL http://jnnp.bmj.com/content/57/6/729.abstract
AB Sixteen patients with primary brain tumours were examined on average eight years after treatment with surgery or whole brain irradiation using standard clinical assessment, CT, a neuropsychological test battery, and single photon emission CT (SPECT) with 99mTc-exametazime. Seventeen lesions were discovered on inspection of SPECT images, 11 with x-ray CT. Quantitative assessment of tracer uptake compared with 16 matched healthy volunteers was consistent with the presence of lesions. Measurement of uptake in brain regions of the hemisphere not containing the primary tumour still showed significant reductions in patients. This may be due to remote direct effects of the tumour or, more likely, to the whole brain irradiation received. Psychometric performance on most tests was significantly impaired in the patient group and was correlated with abnormalities of tracer uptake to relevant brain regions.