RT Journal Article
SR Electronic
T1 Pure autonomic failure: a new case with clinical, biochemical, and necropsy data.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 745
OP 747
DO 10.1136/jnnp.57.6.745
VO 57
IS 6
A1 E van Ingelghem
A1 M van Zandijcke
A1 M Lammens
YR 1994
UL http://jnnp.bmj.com/content/57/6/745.abstract
AB Postmortem examination of a patient with pure autonomic failure showed loss of intermediolateral column cells and of sympathetic ganglionic neurons; there were Lewy bodies in sympathetic neurons. No neuronal loss or Lewy bodies were seen in pigmented brainstem nuclei. This case indicates that pure autonomic failure can occur in the absence of presymptomatic Parkinson's disease. Furthermore, it supports the view that in pure autonomic failure the lesion is more distal than in autonomic failure associated with multiple system atrophy.