RT Journal Article
SR Electronic
T1 Pure motor demyelinating neuropathy: deterioration after steroid treatment and improvement with intravenous immunoglobulin.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 778
OP 783
DO 10.1136/jnnp.57.7.778
VO 57
IS 7
A1 M Donaghy
A1 K R Mills
A1 S J Boniface
A1 J Simmons
A1 I Wright
A1 N Gregson
A1 J Jacobs
YR 1994
UL http://jnnp.bmj.com/content/57/7/778.abstract
AB Within one month of starting oral prednisolone treatment weakness unexpectedly increased in four patients aged 34 to 75 years with purely motor forms of acquired chronic demyelinating neuropathy. By contrast, steroids produced the expected improvement in 11 other patients with symmetric sensorimotor chronic inflammatory demyelinating polyneuropathy. Two of the patients with purely motor demyelinating neuropathy were subsequently treated with high dose IVIg (0.4 g/kg/day for five days) with prompt improvements in strength measurements and motor nerve conduction. Thus IVIg seems to be the treatment of choice and steroids should be used with extreme caution, if at all, in patients with purely motor forms of acquired demyelinating polyneuropathy.