RT Journal Article SR Electronic T1 Chronic fatigue syndrome: a follow up study. JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 617 OP 621 DO 10.1136/jnnp.57.5.617 VO 57 IS 5 A1 D Bonner A1 M Ron A1 T Chalder A1 S Butler A1 S Wessely YR 1994 UL http://jnnp.bmj.com/content/57/5/617.abstract AB Forty-six of 47 patients diagnosed as having chronic fatigue and offered treatment four years previously were followed up. Twenty-nine patients were interviewed, three patients refused an interview, and information on the remaining 14 was obtained from their general practitioners. All the instruments used at interview had been used in the initial study. The long-term prognosis for patients with chronic fatigue syndrome who have initially responded to treatment is good. Spontaneous recovery in those who declined or who did not benefit from treatment is unlikely. Patients who continue to fulfil the criteria for chronic fatigue syndrome four years after they were initially diagnosed are likely to have had more somatic disorders, to have been more fatigued, and to have had a previous psychiatric history when they were initially assessed.