RT Journal Article
SR Electronic
T1 Focal necrotising herpes simplex encephalitis: a report of two cases with good clinical and neuropsychological outcomes.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1115
OP 1117
DO 10.1136/jnnp.57.9.1115
VO 57
IS 9
A1 C E Counsell
A1 R Taylor
A1 I R Whittle
YR 1994
UL http://jnnp.bmj.com/content/57/9/1115.abstract
AB Two patients with atypical focal necrotising herpes simplex encephalitis are described. They presented with relatively mild clinical disease but despite treatment with acyclovir (10 mg/kg/day for three days in case 1 and 10 days in case 2) they developed dramatic, progressive changes (shown on brain CT) that mimicked space occupying lesions of the temporal lobes. Both patients therefore had a diagnostic and therapeutic temporal lesionectomy followed by further 10 day courses of acyclovir. They subsequently went on to make good clinical and neuropsychological recoveries.