TY - JOUR T1 - Exacerbation of postural tremor with emergence of parkinsonism after treatment with neuroleptic drugs. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 487 LP - 489 DO - 10.1136/jnnp.58.4.487 VL - 58 IS - 4 AU - E D Playford AU - T C Britton AU - P D Thompson AU - D J Brooks AU - L J Findley AU - C D Marsden Y1 - 1995/04/01 UR - http://jnnp.bmj.com/content/58/4/487.abstract N2 - Neuroleptic medication in three patients with prior isolated postural arm tremor led to a conspicuous deterioration; the postural tremor increased in amplitude, tremor appeared at rest, and other signs of mild parkinsonism developed. Withdrawal of neuroleptic drugs led to improvement in tremor and disappearance of parkinsonism. Positron emission tomography showed no reduction in uptake of [18F]dopa into nigrostriatal terminals suggesting that these patients did not have Parkinson's disease. Neuroleptic drugs can convert postural essential arm tremor into that characteristic of Parkinson's disease in patients with no evident nigrostriatal lesion. ER -