RT Journal Article
SR Electronic
T1 Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 363
OP 366
DO 10.1136/jnnp.58.3.363
VO 58
IS 3
A1 S Roux
A1 M Grossin
A1 M De Bandt
A1 E Palazzo
A1 F Vachon
A1 M F Kahn
YR 1995
UL http://jnnp.bmj.com/content/58/3/363.abstract
AB Angiotropic large cell lymphoma (ALCL), the so-called malignant angioendotheliomatosis, is characterised by proliferation of tumorous cells within small vessels. Manifestations in the CNS and cutaneous lesions prevail in the clinical presentation, although any organ can be involved. The recent classification of this lymphoma as part of the large cell lymphomas has modified the therapeutic approaches employed. This should improve the prognosis of this usually fatal disease. An unusual case presenting with fever, mononeuritis multiplex, and cutaneous lesions is reported. Peripheral neuropathy without other neurological symptoms is uncommon, and, to our knowledge, such isolated mononeuritis multiplex with nerve lesions has not been previously reported in ALCL. The clinical diagnosis was a systemic necrotising vasculitis and it is considered that its differential diagnosis must include angiotropic large cell lymphoma.