RT Journal Article
SR Electronic
T1 Tau protein concentrations in cerebrospinal fluid of patients with dementia of the Alzheimer type.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 280
OP 283
DO 10.1136/jnnp.59.3.280
VO 59
IS 3
A1 R E Tato
A1 A Frank
A1 A Hernanz
YR 1995
UL http://jnnp.bmj.com/content/59/3/280.abstract
AB Tau protein concentrations were measured in the CSF of 23 patients with dementia of the Alzheimer type (DAT), 36 patients with multi-infarct dementia (MID), and 23 control subjects. Tau protein concentrations were significantly higher in patients with DAT than in controls (P < 0.001) and patients with MID (P < 0.001). A significantly positive correlation between CSF tau protein and glucose concentrations (r = 0.79, P < 0.001) and evolution of disease (r = 0.47, P < 0.05), and a negative correlation with Folstein's mental state examination test (r = -0.73, P < 0.001) were found in patients with DAT.