TY - JOUR T1 - Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 590 LP - 597 DO - 10.1136/jnnp.58.5.590 VL - 58 IS - 5 AU - B Deweer AU - S Lehéricy AU - B Pillon AU - M Baulac AU - J Chiras AU - C Marsault AU - Y Agid AU - B Dubois Y1 - 1995/05/01 UR - http://jnnp.bmj.com/content/58/5/590.abstract N2 - Magnetic resonance based volumetric measures of hippocampal formation, amygdala (A), caudate nucleus (CN), normalised for total intracranial volume (TIV), were analysed in relation to measures of cognitive deterioration and specific features of memory functions in 18 patients with probable Alzheimer's disease. Neuropsychological examination included the mini mental state examination (MMSE), the Mattis dementia rating scale (DRS), tests of executive functions, assessment of language abilities and praxis, the Wechsler memory scale (WMS), the California verbal learning test (CVLT) and the Grober and Buschke test. The volume of the hippocampal formation (HF/TIV) was correlated with specific memory variables: memory quotient and paired associates of the WMS; intrusions and discriminability at recognition for the Grober and Buschke test. By contrast, except for intrusions, no correlations were found between memory variables and the volume of amygdala (A/TIV). No correlations were found between the volume of caudate nuclei (CN/TIV) and any neuropsychological score. The volume of the hippocampal formation was therefore selectively related to quantitative and qualitative aspects of memory performance in patients with probable Alzheimer's disease. ER -