RT Journal Article SR Electronic T1 Neuromuscular disorder as a presenting feature of coeliac disease JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 770 OP 775 DO 10.1136/jnnp.63.6.770 VO 63 IS 6 A1 M Hadjivassiliou A1 A K Chattopadhyay A1 G A B Davies-Jones A1 A Gibson A1 R A Grünewald A1 A J Lobo YR 1997 UL http://jnnp.bmj.com/content/63/6/770.abstract AB OBJECTIVES To describe the range of neuromuscular disorders which may be associated with cryptic coeliac disease. METHODS Nine patients were described with neuromuscular disorders associated with circulating antigliadin antibodies, whose duodenal biopsies later confirmed the diagnosis of coeliac disease. Neurological symptoms antedated the diagnosis of coeliac disease in all, and most had minimal or no gastrointestinal symptoms at the onset of the neuromuscular disorder. RESULTS Three patients had sensorimotor axonal peripheral neuropathy, one had axonal motor peripheral neuropathy, one had probable inclusion body myositis and axonal motor peripheral neuropathy, one had polymyositis and sensorimotor peripheral neuropathy, one had mononeuropathy multiplex, one had neuromyotonia, and one had polyneuropathy. CONCLUSION A wide range of neuromuscular disease may be the presenting feature of coeliac disease. This represents the first report of inclusion body myositis and neuromyotonia associated with coeliac disease. Estimation of circulating antigliadin antibodies should be considered in all patients with neuromuscular disease of otherwise obscure aetiology.