PT  - JOURNAL ARTICLE
AU  - B C Jacobs
AU  - P A van Doorn
AU  - J H Groeneveld
AU  - A P Tio-Gillen
AU  - F G van der Meché
TI  - Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barré syndrome.
AID  - 10.1136/jnnp.62.6.641
DP  - 1997 Jun 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 641--643
VI  - 62
IP  - 6
4099  - http://jnnp.bmj.com/content/62/6/641.short
4100  - http://jnnp.bmj.com/content/62/6/641.full
SO  - J Neurol Neurosurg Psychiatry1997 Jun 01; 62
AB  - To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barré syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barré syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barré syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barré syndrome associated with CMV.