PT - JOURNAL ARTICLE AU - S E Hua AU - F A Lenz AU - T A Zirh AU - S G Reich AU - P M Dougherty TI - Thalamic neuronal activity correlated with essential tremor AID - 10.1136/jnnp.64.2.273 DP - 1998 Feb 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 273--276 VI - 64 IP - 2 4099 - http://jnnp.bmj.com/content/64/2/273.short 4100 - http://jnnp.bmj.com/content/64/2/273.full SO - J Neurol Neurosurg Psychiatry1998 Feb 01; 64 AB - Animal studies suggest that an olivocerebello-bulbospinal pathway mediates harmaline induced tremor, which resembles essential tremor in humans. However, recent evidence suggests that thalamocortical pathways participate in essential tremor. Thalamic single neuron activity has been analysed during thalamotomy for essential tremor. It has been shown by spectral cross correlation analysis that thalamic activity has a significant, linear relation to forearm EMG activity during tremor. The presence of this tremor related activity at the site where a lesion abolishes essential tremor suggests that the thalamus has an important role in the mechanism of essential tremor.